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Info. Vol.14 - No.3 (2020.09.20)
Title Development of a Human Respiratory Mucosa-on-a-chip using Decellularized Extracellular Matrix
Authors Mi Hyun Lim1,2,†, Min Jae Lim1,2,†, Won-Soo Yun3,4, Songwan Jin3,4, Donghyun Lee3,4, Do Hyun Kim 1,* & Sung Won Kim 1,*
Institutions 1Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero Seocho-gu, Seoul 06591, Republic of Korea
2Institute of Clinical Medicine Research, College of Medicine, The Catholic University of Korea, 222, Banpo-daero Seocho-gu, Seoul 06591, Republic of Korea
3T&R Biofab. Co. Ltd. 242 Pangyo-ro, Seongnam-si, Gyeonggi-do 13487, Republic of Korea
4Department of Mechanical Engineering Korea Polytechnic University 237 Sangidaehak-ro, Siheung-si, Gyeonggi-do 15073 Republic of Korea
These authors contributed equally.
*Correspondence and requests for materials should be addressed to D.H. Kim (dohyuni9292@naver.com) and S.W. Kim (kswent@catholic.ac.kr)
Abstract The airway mucosa is the first point of exposure to all inhalant materials. It is possible to produce microenvironments functionally similar to airway by using different types of extracellular matrices around mucosal cells, such as an extracellular matrix decellularized from trachea. In this study, we introduced a novel human respiratory mucosa-on-achip model that uses decellularized tracheal extracellular matrix to assess functional similarities. We also evaluated the effects of respiratory toxicant based on changes in cell viability, tight junction function, oxidative stress, expression of cell adhesion proteins in the vascular network, mucous secretion, and inflammatory cytokine secretion after treatment. This novel human respiratory mucosa-on-a-chip model is expected to be useful for assessing respiratory mucosa reactions to external bacteria or viruses and inhaled drugs.
Keyword Extracellular matrix, Respiratory system, Humans
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